Prenyl transferase inhibitors

Details Prenyl transferase inhibitors Prenyl transferase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/551 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01) C07D 235/00 (2006.01) C07D 241/00 (2006.01) C07D 243/00 (2006.01) C07D 285/00 (2006.01) C07D 513/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2356756

A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by formula (I): wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is A, B, C, D, E, F, G, H, I, J or N(R24R25); and the remaining substituents are as defined in the disclosure.

L'invention concerne une famille de composés imidazoles, utiles pour inhiber l'activité des prényl-transférases. Ces composés sont représentés par la formule générale (I) dans laquelle X représente (CHR?11¿)¿n3?(CH¿2?)¿n4?Z(CH¿2?)¿n5? où Z représente O, N(R?12¿), S, ou une liaison ; Y représente CO, CH¿2?, CS, ou une liaison ; R?1¿ représente A, B, C, D, E, F, G, H, I, J, ou bien N(R?24¿R?25¿); les substituants restants possédant les notations données dans la description.

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