C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 1/04 (2006.01) A61P 1/08 (2006.01) A61P 1/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2583353
The invention relates to 5-HT4 receptor agonists and partial agonists of the formula (I). Novel thienopyridinone compounds and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT4 receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, Parkinson's disease, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, and nonulcer dyspepsia. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
Agonistes du récepteur 5-HT4 et agonistes partiels. Nouveaux composés de thiénopyridinone et leur synthèse et leurs utilisations dans le traitement de maladies induites directement ou indirectement par les récepteurs 5-HT4. Ces états englobent la maladie d'Alzheimer, les troubles cognitifs, le syndrome du côlon irritable, la nausée, les vomissements, la prokinésie, la maladie des reflux gastro-oesophagiens, ainsi que la dyspepsie sans ulcère. Procédés de préparation et nouveaux intermédiaires et leurs sels intermédiaires.
Becker Oren
Chen Dongli
Dhanoa Dale S.
Inbal Boaz
Lobera Mercedes
Borden Ladner Gervais Llp
Epix Delaware Inc.
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