Methods for the treatment of cellular proliferative disorders

Details Methods for the treatment of cellular proliferative disorders Methods for the treatment of cellular proliferative disorders

A - Human Necessities

61

K

A61K 35/76 (2006.01) A61K 39/15 (2006.01) A61K 51/00 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2422245

The present invention relates to methods of identifying the susceptibility of cells to reovirus infection by measuring constitutive MAP kinase pathway signaling. The invention also pertains to methods using reovirus for the treatment of cellular proliferative disorders, and particularly cellular proliferative disorders wherein the proliferating cells exhibit constitutive MEK phosphorylation, in mammals. In particular, the methods provide for reovirus treatment of mammals to treat proliferative disorders, including breast tumors, a subset of tumors in which mutation of the Ras gene is not believed to play a significant role.

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