Targets for therapy and diagnosis of alzheimer's disease and...

Details Targets for therapy and diagnosis of alzheimer's disease and... Targets for therapy and diagnosis of alzheimer's disease and...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2183901

Agents and methods for the diagnosis and therapy of Alzheimer's disease and the related condition Down syndrome are disclosed. Such agents include three genes located within the region of human chromosome 21 occupied by the APP gene, which are exclusively expressed in Alzheimer's disease and Down syndrome, respectively, the proteins encoded and expressed by these genes, and the nucleic acid molecules influencing their expression. Also disclosed are antibodies and nucleotides to detect the presence of the proteins and nucleic acids in humans.

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