Preparation of optically active 2-halopropionic acids

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 53/19 (2006.01) C07B 57/00 (2006.01) C07C 51/09 (2006.01) C07C 51/487 (2006.01)

Patent

CA 2211024

The present invention relates to a process for producing optically active 2-halogen propionic acids in which the corresponding optically active 2-halogen propionic acid alkyl ester is reacted at high temperature with a carboxylic acid in a transacylation reaction to form the optically active 2-halogen propionic acid and the carboxylic acid alkyl ester and the optically active 2-halogen propionic acid is separated from the reaction mixture. The optically active products of the process are important intermediate products for the production of plant protection agents and pharmaceuticals.

L'invention concerne un procédé de préparation de 2-haloacides propioniques à activité optique, selon lequel on fait réagir les esters d'alkyle de 2-haloacides propioniques à activité optique correspondants, à température très élevée, avec un acide carboxylique dans une réaction de transacylation pour former le 2-haloacide propionique à activité optique et l'ester d'alkyle d'acide carboxylique, le 2-haloacide propionique à activité optique obtenu étant ensuite séparé du mélange réactionnel. Les produits à activité optique obtenus selon le procédé constituent des produits intermédiaires importants dans la production de produits phytosanitaires et de produits pharmaceutiques.

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