Mucosal administration of pneumococcal antigens

A - Human Necessities – 61 – K

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Details

A61K 39/02 (2006.01) C07K 14/315 (2006.01) C07K 14/715 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2149703

Mucosal administration, particularly intranasally, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with cholera toxin B subunit, provides protection in animals against pneumococcal colonization and systemic infection. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.

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