C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/06 (2006.01) A61K 31/5377 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2445631
The invention concerns compounds of formula (I), as well as their addition salts with mineral or organic acids, their solvates and/or their hydrates, having strong affinity both for human NK¿2? receptors of neurokinin A and for human NK¿3? receptors of neurokinin B and antagonists of said receptors. The invention also concerns their preparation method, pharmaceutical compositions containing them and their use for preparing medicines.
L'invention concerne des composés de formule: (I), ainsi que leurs sels avec des acides minéraux ou organiques, leurs solvats et/our leur hydrates, présentant une très forte affinité à la fois pour les récepteurs NK2 humains de la neurokinine A et pour les récepteurs NK3 humains de la neurokinine B et étant des antagonistes desdits récepteurs. L'invention concerne également leur procédé de préparation, les compositions pharmaceutiques les contenant et leur utilisation pour la préparation de médicaments.
Emonds-Alt Xavier
Proietto Vincenzo
Kirby Eades Gale Baker
Sanofi-Aventis
Sanofi-Synthelabo
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