C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/30 (2006.01) A61K 31/44 (2006.01) C07B 37/02 (2006.01) C07B 53/00 (2006.01) C07D 213/48 (2006.01) C07D 213/55 (2006.01) C07D 213/85 (2006.01) C07D 263/52 (2006.01)
Patent
CA 2277161
This invention relates to a process for the preparation of a key intermediate in the synthesis of an endothelin antagonist, having formula (I) by using a chiral additive to effect an asymmetric conjugate addition.
L'invention concerne un procédé destiné à un processus de préparation d'un intermédiaire clé, dans la synthèse d'un antagoniste de l'endothéline, cet intermédiaire correspondant à la formule (I) et consistant à utiliser un additif chiral pour induire une addition de conjugué àsymétrique.
Tillyer Richard D.
Tschaen David M.
Xu Feng
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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