Piperidine derivative used for treating chemokine receptor 5...

Details Piperidine derivative used for treating chemokine receptor 5... Piperidine derivative used for treating chemokine receptor 5...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2671460

The present invention relates to 4-[3-(1,1-difluoroethyl)-5-methyl-4H-1,2,4-triazol- 4-yl]-1-{(1R,3R)-3-(3,5-difluorophenyl)-1-methyl-3-[1-(methylsulfonyl).rho.iperidin-4- yl]propyl}piperidine formula (I): or a pharmaceutically acceptable salt thereof, as well as processes for the preparation of this compound and its use in the treatment of CCR5 disease states.

La présente invention concerne une 4-[3-(l,l-difluoroéthyl)-5-méthyl-4H-l,2,4-triazol-4-yl]-l-{(lJR,3i?)-3-(3,5-difluorophényl)-l-méthyl-3-[l-(méthylsulfonyl).rho.ipéridin-4-yl]propyl}pipéridine (I) : ou l'un de ses sels acceptables d'un point de vue pharmaceutique, ainsi que des procédés de préparation de ce composé et son utilisation dans le traitement d'états pathologiques du CCR5.

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