Induction of a cellular stress response with heavy metal salts

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/24 (2006.01) A61K 33/26 (2006.01) A61K 33/30 (2006.01) A61K 33/32 (2006.01) A61K 33/34 (2006.01)

Patent

CA 2268247

The present invention relates to compositions and methods of induction of a cellular stress response and a protected phenotype using heavy metal ions. The invention relates to methods of protecting a mammal against injury caused by a noxious condition by administering to the mammal a heavy metal in sufficient quantity and under appropriate conditions to induce a sufficient cellular stress response to provide protection (partial or complete) against injury caused by a noxious condition. The invention also relates to methods of inducing a cellular stress response in a mammal by administering a heavy metal in sufficient quantity and under appropriate conditions to induce a cellular stress response to protect the mammal against injury caused by a noxious condition. The invention also relates to compositions comprising a heavy metal, and an additional component, such as a stress protein, agents which enhance a cellular stress response, aid in the uptake of heavy metal into the tissue, or have a synergistic effect with heavy metals, stress proteins and/or other agents for the induction of the cellular stress response.

L'invention concerne des compositions et des procédés servant à provoquer une réaction au stress cellulaire et un phénotype protégé au moyen d'ions de métaux lourds. Elle concerne des procédés servant à protéger un mammifère contre des troubles provoqués par des conditions nuisibles et consistant à administrer à ce mammifère un métal lourd en quantité suffisante et dans des conditions appropriées à la provocation d'une réaction suffisante au stress cellulaire pour créer une protection (partielle ou totale) contre des troubles provoqués par des conditions nuisibles. Elle concerne également des procédés servant à provoquer une réaction au stress cellulaire chez un mammifère et consistant à administrer un métal lourd en quantité suffisante et dans des conditions appropriées à la provocation d'une réaction au stress cellulaire afin de protéger ce mammifère contre des troubles provoqués par des conditions nuisibles. Elle concerne encore des compositions contenant un métal lourd, ainsi qu'un constituant additionnel, tel qu'une protéine de stress, des agents amplifiant la réaction au stress cellulaire, facilitant l'absorption du métal lourd dans le tissu et exerçant un effet synergique avec les métaux lourds, les protéines de stress ou d'autres agents servant à provoquer la réaction au stress cellulaire.

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