Human sel-10 polypeptides and polynucleotides that encode them

Details Human sel-10 polypeptides and polynucleotides that encode them Human sel-10 polypeptides and polynucleotides that encode them

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2309391

The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel- 10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A.beta. processing is altered.

Cette invention se rapporte à des molécules d'acides nucléiques isolées contenant un polynucléotide qui code l'un ou l'autre des deux variants d'épissage alternatif du polypeptide Sel-10 humain, dont l'un est exprimé dans les cellules hyppocampiques et dont l'autre est exprimé dans les cellules mammaires. Cette invention se rapporte également à des polypeptides Sel-10 isolés et à des lignées cellulaires qui expriment ces polypeptides et dans lesquelles la transformation de l'élément A.beta. est modifiée.

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