A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4409 (2006.01) A61K 31/00 (2006.01) A61K 31/415 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/4458 (2006.01) A61K 31/4462 (2006.01) A61K 31/4465 (2006.01) A61K 31/4545 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 45/00 (2006.01) A61P 13/12 (2006.01) A61P 43/00 (2006.01) C07D 213/75 (2006.01) C07D 213/81 (2006.01) C07D 213/89 (2006.01) C07D 231/40 (2006.01) C07D 237/20 (2006.01) C07D 239/50 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 40
Patent
CA 2404594
A compound having a Rho kinase inhibitory activity, such as (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)--cyclohexane, has a renal interstitial fibrosis inhibitory action in renal interstitial fibrosis model mice and various other actions, and therefore, is useful as an agent for the prophylaxis or treatment of renal diseases.
La présente invention concerne des composés ayant une activité d'inhibition de Rho-kinase (par exemple, (+)-trans-4-(1-aminoéthyl)-1-(4-pyridylcarbamyl)cyclohexane), qui, en raison de l'effet d'inhibition qu'ils exercent sur la fibrose néphrointerstitielle et des autres effets exercés sur une souris de laboratoire à fibrose néphrointerstitielle, peuvent être utilisés comme agents de prévention et remèdes contre les maladies rénales.
Imai Enyu
Moriyama Toshiki
Fetherstonhaugh & Co.
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
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