C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 205/08 (2006.01) C07D 305/14 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 407/12 (2006.01) C07D 413/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2154071
Taxol TM is a complex diterpene which is currently considered the most exciting lead in cancer chemotherapy. Taxol possesses high cytotoxicity and strong antitumor activity against different cancers which have not been effectively treated by existing antitumor drugs. However, Taxol has a problem with solubility in aqueous media, which may impose some serious limitation in its use. Taxotere seems to have antitumor activity superior to Taxol with better bioavailability. Taxotere has a modified Taxol structure with a modified C-13 side chain. This fact strongly indicates that modification on the C-13 side chain would provide a new series of Taxol and Taxotere analogues which may have higher potency, better bioavailability and less unwanted toxicity. The present invention provides efficient and practical methods for the syntheses of Taxotere and its analogues of the formula: (see formula I) through .beta.-lactam intermediates of the formula: (see formula II) and their coupling with a metal alkoxide baccatin III derivative of formula: (see formula III)
Ojima Iwao
Smart & Biggar
The Research Foundation Of State University Of New York
LandOfFree
Process for preparation of taxane derivatives and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparation of taxane derivatives and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of taxane derivatives and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1990308