Antigen binding fragments that specifically detect cancer...

Details Antigen binding fragments that specifically detect cancer... Antigen binding fragments that specifically detect cancer...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2255540

The present invention relates to monoclonal antibody H11 and antigen binding fragments that specifically bind to the antigen recognized by H11, the C-antigen. The C-antigen is found specifically on neoplastic cells and not on normal cells. Also disclosed are polynucleotide and polypeptide derivatives based on H11, including single chain V region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the H11 antibody is effective in diagnosing, localizing, and/or treating neoplasias. The invention further provides methods for treating a neoplastic disease, particularly melanoma, neuroblastoma, glioma, soft tissue sarcoma, and small cell lung carcinoma. Patients who are in remission as a result of traditional modes of cancer therapy may be treated with a composition of this invention in hopes of reducing the risk of recurrence. Patients may also be treated concurrently with the antibodies and traditional anti-neoplastic agents.

La présente invention concerne des anticorps monoclonaux H11 et des fragments de liaison à l'antigène qui se lient spécifiquement à l'antigène reconnu par H11, l'antigène C. Cet antigène C se trouve de façon spécifique sur les cellules néoplasiques et non pas sur les cellules normales. L'invention concerne également des dérivés de polynucléotides et de polypeptides à base de H11, y compris des molécules monocaténaires à régions variables et des protéines de fusion, ainsi que diverses compositions pharmaceutiques. Lorsqu'il est administré à un individu, l'anticorps H11 permet de diagnostiquer, de localiser et/ou de traiter des néoplasies. L'invention concerne en outre des méthodes pour traiter les affections néoplasiques, en particulier, les mélanomes, les neuroblastomes, les gliomes, les sarcomes des tissus mous, et les carcinomes pulmonaires à petites cellules. Les patients en rémission suite à des modes traditionnels de thérapie du cancer peuvent être traités avec une composition de l'invention, dans l'espoir de réduire les risques de récurrence. Les patients peuvent également être traités en parallèle avec des anticorps et des agents antinéoplasiques traditionnels.

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