Synthesis of acyclic nucleoside derivatives

Details Synthesis of acyclic nucleoside derivatives Synthesis of acyclic nucleoside derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01) C07C 69/003 (2006.01) C07C 69/66 (2006.01) C07C 229/24 (2006.01) C07D 473/40 (2006.01)

Patent

CA 2277151

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

La présente invention concerne des procédés et de nouveaux intermédiaires permettant de préparer des dérivés de nucléoside acyclique répondant à la formule (I), dans laquelle R1 et R2 sont l'un, un groupe acide aminé acyle et l'autre, un -C(O)C3-C21 saturé ou monoinsaturé, facultativement alkyle substitué, et R3 est OH ou H; ou un sel pharmaceutiquement acceptable de ces derniers.

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