Modified antibody fab fragments

Details Modified antibody fab fragments Modified antibody fab fragments

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2527020

The present invention provides antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1. Also provided are antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1 to which one or more effector molecules are attached.

La présente invention se rapporte à des fragments d'anticorps Fab, dans lesquels la région constante de la chaîne lourde se termine au niveau de la cystéine intercaténaire de C<SB>H</SB>1. L'invention concerne également des fragments d'anticorps Fab, dans lesquels la région constante de la chaîne lourde se termine au niveau de la cystéine intercaténaire de C<SB>H</SB>1, et auxquels sont liées une ou plusieurs molécules effectrices. ?¿

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