Manufacturing process for sample initiated assay device

G - Physics – 01 – N

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G01N 33/558 (2006.01) B01L 3/00 (2006.01) C12Q 1/00 (2006.01) G01N 33/52 (2006.01) G01N 35/00 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2128517

2128517 9315404 PCTABS00024 The quantitative test device is manufactured by attaching the critical component of a two-component dye system to minute particles such as microcrystalline cellulose, silica, or latex, which particles are suspended in a solution of a polymeric binder. Additional non-immobilized components of the reaction system of the test device are optionally added to the polymer solution. The suspension of dyed particles in polymer solution is applied to a fabric as a coating, using conventional coating machines, to obtain a homogeneous distribution of immobilized dye throughout the fabric. The measurement zone is made from a film support made of a material having a lower melting point than the filter cloth fabric used in the measurement zone was used. By using a lower melting point material for the support film, impulse heat sealing is controlled to a degree such that the lower melting point support is made to melt and extrude through the mesh of the fabric on either side of the channel, forming a seal along the sides of the channel. The device may be manufactured using a feedback loop which allows one to modify continuously the dimensions of a reading scale printed on the device.

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