Compositions comprising epithelial cells for the treatment...

A - Human Necessities – 61 – L

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A61L 27/38 (2006.01) A61L 24/00 (2006.01) A61L 24/10 (2006.01) A61L 27/44 (2006.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01)

Patent

CA 2495818

Compositions and methods are described for the treatment and prevention of abdominal and thoracic adhesions as well as other adhesions using a cell- sustaining and surface-separating composition that nourishes and sustains grafted or present non-keratinizing (i.e. nonepidermal) epithelial cells. The composition is preferably a suspension of viable epithelial cells in a polymerizable, absorbable composition, such as fibrin glue, that will provide separation of the organ surfaces and nourishment to seeded and grafted cells.

Cette invention se rapporte à des compositions et à des procédés servant au traitement et à la prévention des adhésions abdominales et thoraciques, ainsi que d'autres adhésions, au moyen d'une composition de soutien des cellules et de séparation des surfaces qui nourrit et soutient les cellules épithéliales non kératinisantes (c'est-à-dire non épidermiques) présentes ou greffées. Cette composition est de préférence constituée par une suspension de cellules épithéliales viables dans une composition absorbable polymérisable, telle que de la colle de fibrine, qui va séparer les surfaces des organes et nourrir les cellules ensemencées et greffées.

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