A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/685 (2006.01) A61K 31/00 (2006.01) A61K 31/661 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2480429
The present invention relates to novel therapeutical use of agonist ligands specific to G2A receptor. More particularly, the present invention relates to methods for treating a disease or disorder associated with neutrophil accumulation and hyperactivity and/or excessive release of IL-8, or with microbial infection, in a subject, comprising administering LPC (lysophosphatidylcholine), SPC(sphingophosphorylcholine) or derivatives thereof to the subject. The agonist ligands for G2A receptor according to the present invention and pharmaceutical- or therapeutical composition comprising said ligands can be used effectively in treatment of a disease or disorder associated with neutrophil accumulation and hyperactivity and/or excessive release of IL-8, specifically inflammatory diseases and diseases associated with ischemia-reperfusion injury as well as microbial infection.
L'invention concerne une nouvelle utilisation thérapeutique de ligands agonistes spécifiques du récepteur G2A. L'invention concerne notamment des méthodes de traitement d'une maladie ou d'un trouble associé(e) à l'accumulation de neutrophiles et à l'hyperactivité et/ou à la libération excessive d'IL-8, ou à l'infection microbienne, chez un sujet, méthodes consistant à administrer de la LPC (lysophosphatidylcholine), de la SPC (sphingophosphorylcholine) ou des dérivés de celles-ci audit sujet. Les ligands agonistes pour le récepteur G2A de l'invention et une composition pharmaceutique ou thérapeutique contenant lesdits ligands peuvent être utilisés efficacement dans le traitement d'une maladie ou d'un trouble associé à l'accumulation de neutrophiles, à l'hyperactivité et/ou à la libération excessive d'IL-8, notamment de maladies inflammatoires et de maladies associées à l'ischémie ou à la lésion de reperfusion ainsi qu'à l'infection microbienne.
Huh Sung-Oh
Kim Yung-Hi
Song Dong-Keun
Suh Hong-Won
Arimed Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biosynergen Inc.
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