A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2324138
This invention provides a screen to identify novel therapeutic receptor-ligand pairs. In one embodiment, the receptor-ligand pairs identified by this method induce proliferation of tumor-infiltrating lymphocytes without systemic toxicity associated with the administration of wild-type cytokines. Diagnostic and therapeutic methods using the cytokine-receptor pairs identified by this screen also are provided.
L'invention porte sur un crible permettant d'identifier de nouvelles paires de récepteurs/ligands à usage thérapeutique. Dans l'une des versions les paires identifiées par cette méthode induisent la prolifération de lymphocytes infiltrant les tumeurs sans la toxicité systémique liée à l'administration de cytokines de type sauvage. L'invention porte également sur des méthodes diagnostiques et thérapeutiques utilisant les paires identifiées au moyen dudit crible.
Genzyme Corporation
Gowling Lafleur Henderson Llp
LandOfFree
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