N-substituted-furylalkenyl hydroxamic acid and n-hydroxyurea...

Details N-substituted-furylalkenyl hydroxamic acid and n-hydroxyurea... N-substituted-furylalkenyl hydroxamic acid and n-hydroxyurea...

C - Chemistry, Metallurgy

07

D

C07D 307/56 (2006.01) A61K 31/34 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/695 (2006.01) C07D 307/58 (2006.01) C07D 307/64 (2006.01) C07D 405/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2117381

(SEE FIGURE I) Compounds useful in inhibiting the biosynthesis of leukotrienes have structure (I), where M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group, R4 is alkyl, cycloalkyl or -NR5R6, where R5 and R5 are hydrogen, alkyl cycloalkyl or alkanoyl, where A is a valence bond or is a straight or branched divalent alkylene group of from one to twelve carbon atoms, R2 and R3 are independently selected from hydrogen, straight or branched alkyl of from one to twelve carbon atoms, halogen, or trifluoroalkyl, and R1 is selected from phenoxy, phenylthio, 2-, 3-, or 4-pyridyloxy, 1-, or 2- naph-thyloxy, or 2-, 4-, 5-, or 8-quinolytoxy all optionally substituted with alkyl, haloalkyl, alkoxy, hydroxy or halogen.

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