Novel proteins and nucleic acids encoding same

Details Novel proteins and nucleic acids encoding same Novel proteins and nucleic acids encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2440337

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

L'invention concerne des polynucléotides isolés et des polypeptides, cibles de petites molécules, codés par ces polynucléotides. Elle concerne aussi des anticorps qui se lient de façon immunospécifique à un polypeptide, cible de petites molécules, ou tout dérivé, variant, mutant ou fragment de ces polypeptide, polynucléotide ou anticorps, ainsi que des procédés dans lesquels le polypeptide, cible de petites molécules, le polynucléotide et l'anticorps sont utilisés dans la détection et le traitement d'un large éventail d'états pathologiques. Elle concerne plus spécifiquement des procédés utilisant des protéines exprimées par recombinaison, ou d'expression endogène, dans différentes procédures de criblage destinées à l'identification d'anticorps thérapeutiques et de petites molécules thérapeutiques associés à des maladies.

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