C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/502 (2006.01) A61K 31/5025 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/538 (2006.01) A61K 31/5415 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2519297
The present invention is directed to compounds of the formula (I) Wherein A, B, D, X, Y, n, R1, R3, R4, R5, R15, R16, R17, R18 and the dashed line are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
L'invention concerne des composés de formule (I) dans laquelle A, B, D, X, Y, n, R?1¿, R?3¿, R?4¿, R?5¿, R?15¿, R?16¿, R?17¿, R?18¿ et la ligne pointillée sont définis dans la description, utiles comme modulateurs de l'activité des récepteurs des chimiokines. Plus précisément, ces composés sont utiles comme modulateurs du récepteur des chimiokines CCR-2.
Goble Stephen D.
Mills Sander G.
Pasternak Alexander
Yang Lihu
Zhou Changyou
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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