C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) C07D 233/40 (2006.01) C07D 233/42 (2006.01) C07D 233/66 (2006.01) C07K 5/02 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2101179
Phenylimidazolidine derivatives of the general formula I (see formula I) in which, for example, Y denotes -CH2-CH2-CO-, r denotes 0 to 3, Z denotes oxygen, W denotes hydroxyl, R1 denotes -NH-C(=NH)-NH2, R, R2, R3 denote hydrogen, R4 denotes -CO-NHR5, where -NH-R5 represents an .alpha.-amino acid radical, have the ability to inhibit cell-cell adhesion. They are useful as inhibitors of platelet aggregation, thromboses, metastasis of carcinoma cells and osteoclast binding to the bone surfaces.
Breipohl Gerhard
Jablonka Bernd
Just Melitta
Klingler Otmar
Knolle Jochen
Cassella Aktiengesellschaft
Fetherstonhaugh & Co.
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