Therapeutic intervention to mimic the effect of caloric...

A - Human Necessities – 61 – K

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A61K 31/202 (2006.01) A61K 31/00 (2006.01) A61K 31/137 (2006.01) A61K 31/19 (2006.01) A61K 31/20 (2006.01) A61K 31/201 (2006.01) A61K 31/215 (2006.01)

Patent

CA 2388754

Methods are provided for promoting longevity and decreasing the incidence of aging associated pathologies (e.g., cancer) by the administration of one or more of the following LFFA: linoleic, oleic and palmitic acid. Secondary LFFA derived from this set, as well as their CoA derivatives and synthetic analogs, are effective also in promoting longevity and delaying the onset of age associated disorders. In addition, interventions including LFFA and CoA LLFA formulations are described which protect the organism from acute physical stress, tissue damage and hypoxia (either due to trauma or secondary to surgical procedures).

L'invention porte sur des procédés visant à augmenter la longévité et réduire le vieillissement associé à des pathologies (telles que le cancer) en administrant un ou plusieurs des acides gras libres à longue chaîne suivants : l'acide linoléique, l'acide oléique et l'acide palmitique. Les acides gras libres à longue chaîne secondaires dérivés de cet ensemble ainsi que leurs dérivés CoA et leurs analogues synthétiques sont également efficaces pour accroître la longévité et retarder le vieillissement associé à des pathologies. De plus, des interventions comprenant des formulations d'acides gras libres à longue chaîne et des dérivés CoA de ceux-ci protègent l'organisme d'un stress physique intense, des lésions tissulaires et de l'hypoxie (imputables à un trauma ou aux effets secondaires des interventions chirurgicales).

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