C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 381/00 (2006.01) A61K 31/155 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2486336
Pentafluorosulfanylbenzoylguanidines of the formula I and II (see formula I) (see formula II) in which R1 to R4 have the meanings stated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.
La présente invention concerne des pentafluorsulfanyl-benzoyl-guanidines de formule (I) et (II) dans lesquelles R1 à R4 ont les correspondances indiquées dans les revendications, qui sont utilisées en tant que produits pharmaceutiques anti-arythmie comprenant des composantes de protection cardiaque, pour prévenir ou traiter l'infarctus et traiter l'angine de poitrine. Elles inhibent également de façon préventive les phénomènes patho-physiologiques en cas de dommages induits par l'ischémie, notamment lors du déclenchement d'arythmies induites par l'ischémie.
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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