Estrogenic extracts of rheum palmatum l of the polygonaceae...

Details Estrogenic extracts of rheum palmatum l of the polygonaceae... Estrogenic extracts of rheum palmatum l of the polygonaceae...

A - Human Necessities

61

K

A61K 36/708 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2698740

Extracts of various species of the Polygonaceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Rheum palmatum L of the Polygonaceae family species possess estrogenic properties in both ER.alpha.+ and ER.beta.+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.

L'invention concerne des extraits de diverses espèces de la famille Polygonaceae présentant des propriétés oestrogéniques. Par exemple, des extraits aqueux et éthanoliques de Rheum palmatum L de la famille Polygonaceae possèdent des propriétés oestrogéniques à la fois dans les cellules ERa+ et ERß+. Les effets oestrogéniques sont la stimulation de l'élément de réponse aux oestrogènes (ERE), ainsi que la répression du facteur de nécrose tumorale (TNF). L'invention concerne également des méthodes de traitement des symptômes du climatère, du cancer du sein et/ou de l'utérus et de l'ostéoporose

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