Peptide diagnostic agent for lyme disease

Details Peptide diagnostic agent for lyme disease Peptide diagnostic agent for lyme disease

C - Chemistry, Metallurgy

07

K

C07K 14/20 (2006.01) C07K 7/08 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2708753

The present invention relates, e.g., to an isolated peptide comprising the sequence MKKNDQI(V or G)AAIALRGVA (SEQ ID NO:64), wherein the peptide is no longer than 24 amino acids, and wherein the peptide can bind specifically to an antibody induced by a causative agent of Lyme disease (a pathogenic Borrelia), e.g. in a sample from a subject having Lyme disease. Embodiments of this peptide include, e.g., peptides comprising the sequence MKKNDQIVAAIALRGVA (SEQ ID NO:65) or MKKNDQIGAAIALRGVA (SEQ ID NO:66). Also disclosed are linear multimeric peptides that contain the peptide represented by SEQ ID NO:64 as well as one or more additional peptide epitopes from other Borrelia proteins that can also bind specifically to an antibody as above. Compositions and diagnostic kits comprising a peptide of the invention are described, as are diagnostic assays using the peptide(s).

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