Staphylococcus aureus genes and polypeptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) C07K 14/31 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12N 15/66 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2341311

The present invention relates to novel genes from S. aureus and the polypeptides they encode. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of S. aureus polypetide activity. The invention additionally relates to diagnostic methods for detecting Staphylococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Staphylococcus.

La présente invention concerne de nouveaux gènes provenant de S. aureus et les polypeptides qu'ils codent. On décrit également des vecteurs, des cellules hôtes, des anticorps et des procédés de recombinaison utilisés pour produire ces derniers; ainsi que des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité du polypeptide S. aureus. L'invention concerne en outre des procédés de diagnostic utiles pour détecter des acides nucléiques, des polypeptides et des anticorps de Staphylococcus dans un échantillon biologique, ainsi que de nouveaux vaccins permettant de prévenir ou d'atténuer l'infection par le Staphylococcus.

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