Inhibition of viral infection and spread with viral and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/135 (2006.01) C07K 14/16 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2336612

Isolated peptides, peptidomimetics, and antibodies which bind to the viral fusion protein binding domain of the RhoA protein or the RhoA binding domain of a viral fusion protein are useful for inhibiting infection in susceptible cells, in vitro and in vivo. Among these viruses are the Paramyxovirus respiratory syncytial virus (RSV) and the Lentivirus human immunodeficiency virus (HIV).

L'invention concerne des peptides isolés, des peptidomimétiques et des anticorps qui se lient au domaine de liaison des protéines de fusion virale de la protéine RhoA ou au domaine de liaison RhoA d'une protéine de fusion virale. Ils peuvent servir à inhiber l'infection dans les cellules réceptives, in vitro comme in vivo. Parmi ces virus on peut mentionner le Paramyxovirus RSV, ou virus respiratoire syncytial, et le Lentivirus VIH, ou virus de l'immunodéficience humaine.

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