Polymorphs of telmisartan, processes for preparing them and...

Details Polymorphs of telmisartan, processes for preparing them and... Polymorphs of telmisartan, processes for preparing them and...

C - Chemistry, Metallurgy

07

D

C07D 235/18 (2006.01) A61K 31/4184 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2352436

The invention relates to polymorphs of 4'-[2-n-propyl-4- methyl-6-(1-methylbenzimidazol-2-yl)benzimidazol-1- ylmethyl]biphenyl-2-carboxylic acid (INN: telmisartan), particularly polymorphic form B, mixtures of the polymorphs, processes for preparing telmisartan containing form B and the use thereof for preparing a pharmaceutical composition.

L'invention concerne des polymorphes de 2-acide carboxylique 4'-[2-n-propyl-4-méthyl-6-(1-méthylbenzimidazol-2-yl)benzimidazol-1-ylméthyl]biphényle (INN: Telmisartane), notamment la forme polymorphe B (I), qui se caractérisent en ce qu'ils présentent un maxima endothermique à 183+/-2 DEG C, intervenant au cours de l'analyse thermique par calorimétrie par échantillonnage différentiel. L'invention concerne des mélanges des polymorphes, des procédés permettant de préparer du Telmisartane contenant la forme B et son utilisation pour préparer un médicament.

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