Immunotherapeutic treatment for inducing the regression of...

Details Immunotherapeutic treatment for inducing the regression of... Immunotherapeutic treatment for inducing the regression of...

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 31/33 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 9/10 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2621017

The use of immunotherapy against oxidised LDL to induce regression of preexisting atherosclerotic lesions in an individual. The immunotherapy can be passive immunotherapy utilising antibodies that bind to epitopes present on oxidised LDL, or active immunotherapy utilising a vaccine composition for induction of an immune response against epitopes present on oxidised LDL.

L'invention concerne l'utilisation de l'immunothérapie contre la LDL oxydée pour induire une régression des lésions athéroscléreuses préexistantes chez un individu. Cette immunothérapie peut être une immunothérapie passive utilisant des anticorps qui se lient à des épitopes présents sur la LDL oxydée ou une immunothérapie active utilisant une composition vaccinale pour induire une réponse immunitaire contre des épitopes présents sur la LDL oxydée.

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