Production of tissue factor pathway inhibitor

Details Production of tissue factor pathway inhibitor Production of tissue factor pathway inhibitor

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2196296

A method for the production of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Pathway Inhibitor 2 (TFPI-2) and muteins thereof is disclosed wherein the protein is retained within a yeast cell during growth of the yeast cell and recovered from an insoluble fraction prepared from yeast cells containing the protein.

Procédé de production d'inhibiteur des voies du facteur tissulaire de la coagulation (TFPI) et d'inhibiteur des voies du facteur tissulaire de la coagulation 2 (TFPI-2) et de mutéines desdits inhibiteurs, selon lequel la protéine est retenue dans une cellule de levure durant la croissance de celle-là et récupérée à partir d'une fraction insoluble préparée à base de cellules de levure contenant ladite protéine.

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