A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/42 (2006.01) A61K 9/10 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01)
Patent
CA 2752902
This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.
Cette invention porte, par exemple, sur une composition appropriée pour une administration pour le système nerveux central (SNC), comprenant un hydrogel de co-polypeptide à bloc, qui comprend un matériau biologiquement actif qui est mélangé avec l'hydrogel ou qui est fixé à la chaîne de polypeptide de l'hydrogel, la composition étant appropriée pour une administration au SNC. L'invention porte également sur des procédés de fabrication et d'utilisation des compositions de l'invention sous forme de dépôts ou sous forme d'échafaudages pour la migration cellulaire, et sur des compositions pharmaceutiques et coffrets pour mettre en uvre les procédés de l'invention.
Ao Yan
Deming Timothy J.
Sofroniew Michael V.
Song Bingbing
Yang Chu-Ya
Cameron Mackendrick Llp
The Regents Of The University Of California
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