C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 7/64 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) C12N 15/52 (2006.01) C12P 21/00 (2006.01) C12P 21/04 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2675024
In various aspects, the invention provides methods for cyclizing proteins, including methods for enhancing the stability of cyclized proteins under cytosolic conditions. The invention also provides various methods for using the cyclized proteins. For example, cyclized proteins of the invention may be used in screening assays analogous to the yeast two hybrid assay. Selected embodiments of the invention provide cyclized single chain variable fragment (ScFv) molecules, including molecules in the form of an immunoglobulin fold.
L'invention porte dans ses divers aspects sur des méthodes de cyclisation de protéines y compris des méthodes augmentant la stabilité de protéines cyclisées dans des conditions cytosoliques. L'invention porte également sur diverses méthodes d'utilisation de protéines cyclisées qui peuvent par exemple servir dans des essais de criblage analogues aux essais à double hybride de levure. Certaines exécutions sélectionnées de l'invention portent sur des molécules cyclisées de fragments variables à chaîne simple (ScFv), dont des molécules d'immunoglobuline repliée.
Barreto Kris Michael
Geyer Clarence Ronald
Smart & Biggar
University Of Saskatchewan
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