Polyene polyketides and methods of production

Details Polyene polyketides and methods of production Polyene polyketides and methods of production

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 31/164 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/35 (2006.01) A61K 31/357 (2006.01) A61K 31/7028 (2006.01) A61P 31/04 (2006.01) C07C 229/30 (2006.01) C07C 237/16 (2006.01) C07C 279/12 (2006.01) C07C 279/14 (2006.01) C07D 309/10 (2006.01) C07D 493/04 (2006.01) C07H 15/10 (2006.01) C07H 15/18 (2006.01) C12P 1/06 (2006.01) C12P 13/00 (2006.01) C12P 17/10 (2006.01) C12P 19/44 (2006.01)

Patent

CA 2484638

Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC .TM. 43491 or a mutant or variant such as the strain IDAC-220604-1. Another method for obtaining the compounds is post-biosynthesis chemical modification of the compounds obtained by cultivation. Novel polynucleotide sequences and encoded proteins for the biosynthesis of the polyene polyketides are also presented.

L'invention concerne de nouvelles polykétides de polyène, leurs sels pharmaceutiquement acceptables, leurs promédicaments et leurs dérivés présentant une activité antibiotique. L'invention concerne une méthode permettant d'obtenir des composés par la culture d'Amycolatopsis orientalis ATCC(TM) 43491 ou un mutant ou un variant, notamment la souche IDAC-220604-1. L'invention concerne une autre méthode pour obtenir des composés. Cette méthode consiste à modifier chimiquement la post-biosynthèse des composés obtenus par la culture susmentionnée. L'invention concerne également des séquences polynucléotidiques et des protéines codées pour la biosynthèse de polyketides de polyène. Formule (I).

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