Clavulanic acid derivatives, a process for their preparation...

Details Clavulanic acid derivatives, a process for their preparation... Clavulanic acid derivatives, a process for their preparation...

A - Human Necessities

61

K

167/187

A61K 31/42 (2006.01)

Patent

CA 1148085

ABSTRACT OF THE DISCLOSURE A synergistic pharmaceutical composition comprising a compound of the formula (II): Image (II) or an ester thereof of the formula (III) or (IV). (III) Image (IV) wherein A1 is an alkyl group of 1-6 carbon atoms optionally substituted by an alkoxyl or acyloxyl group of 1-7 carbon atoms; A2 is an alkenyl or alkynyl group of up to 5 carbon atoms or is a phenyl group optionally substituted by a fluorine, chlorine, bromine, nitro or alkyl or alkoxyl of up to 4 carbon atoms; and A3 is a hydrogen atom, an alkyl group of up to 4 carbon atoms or a phenyl group optionally substituted by a fluorine, chlorine, bromine, nitro or alkyl or alkoxyl of up to 4 carbon atoms; or pharmaceutically acceptable acid addition salts thereof together with a .beta.-lactam antibiotic selected from penicillins and cephalosporins and their pharmaceutically acceptable salts and esters and a pharmaceutically acceptable carrier therefor.

399886

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