Compositions comprising hypsizygus ulmarius extract

A - Human Necessities – 61 – K

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Details

A61K 36/07 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2623777

Disclosed are topical compositions comprising extracts of Hypsizygus ulmarius in amounts that are effective to influence LTB4-mediated chemotaxis and/or IL- 1.beta. mediated adhesion of polymorphonuclear leukocytes. The hypsizygus ulmarius extract may be used alone or in combination with secondary anti- inflammatory and skin active agents, such as other mushroom and/or natural extracts. The secondary anti-inflammatory agents may or may not function by antagonizing LTB4-mediated chemotaxis and IL-1.beta. mediated adhesion. The extract may be incorporated into a cosmetically acceptable vehicle. The present invention includes methods of treating skin inflammation by applying to inflamed skin, anti-inflammatory effective amounts of Hypsizygus ulmarius extract in a defined treatment regimen.

La présente invention porte sur des préparations à usage local comprenant des extraits de Hypsizygus ulmarius en des teneurs suffisantes pour influencer la chimiotaxie faisant intervenir LTB4 et/ou l'adhésion de leucocytes polymorphonucléaires faisant intervenir IL-1.beta.. L'extrait de hypsizygus ulmarius peut être employé seul ou combiné à des agents actifs cutanés et anti-inflammatoires secondaires, tels que d'autres extraits naturels et/ou de champignons. Les agents anti-inflammatoires secondaires peuvent éventuellement agir en tant qu'antagonistes de la chimiotaxie faisant intervenir LTB4 et de l'adhésion faisant intervenir IL-1.beta.. L'extrait peut être incorporé dans un vecteur de qualité cosmétique. La présente invention inclut des méthodes de traitement d'inflammations cutanées par application à la peau subissant l'inflammation de quantités suffisantes pour obtenir un effet anti-inflammatoire d'extraits de Hypsizygus ulmarius dans un régime de traitement défini.

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