A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/553 (2006.01) A61K 31/395 (2006.01) A61K 31/4184 (2006.01) A61K 31/55 (2006.01) A61K 38/02 (2006.01) A61K 45/00 (2006.01) A61L 2/16 (2006.01) A61P 31/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01)
Patent
CA 2489943
The current invention is based, inter alia, on the finding that the transcription factor MarA, and homologues of MarA, e.g., Rob and SoxS, are virulence factors. Accordingly, the invention discloses methods for screening compounds for their ability to modulate these virulence factors. The invention further describes methods for treating and preventing bacterial infections by modulating the expression and/or activity of transcription factors. In addition, the invention provides a method for identifying other virulence factors.
La pr~sente invention s'appuie, notamment, sur la d~couverte que le facteur de transcription MarA et des homologues de MarA, tels que Rob et SoxS, sont des facteurs de virulence. Par cons~quent, l'invention concerne des m~thodes de criblage de compos~s capables de moduler ces facteurs de virulence. L'invention concerne ~galement des m~thodes de traitement et de pr~vention d'infections bact~riennes qui consistent ~ moduler l'expression et/ou l'activit~ de facteurs de transcription. De plus, l'invention concerne une m~thode permettant d'identifier d'autres facteurs de virulence.
Alekshun Michael N.
Levy Stuart B.
Borden Ladner Gervais Llp
Paratek Pharmaceuticals Inc.
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