Uses of an endothelial cell receptor

Details Uses of an endothelial cell receptor Uses of an endothelial cell receptor

G - Physics

01

N

G01N 33/566 (2006.01) A61K 38/48 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) G01N 33/543 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2471417

The subject invention relates to uses of a receptor referred to as GRP78 and to other endothelial cell receptors which bind to the kringle 5 region of mammalian plasminogen. More specifically, identification of the functional properties of this receptor and other such receptors allows for the development and screening of agents which, for example, mimic K5 (i.e, mimetics) and therefore inhibit angiogenesis.

La présente invention concerne des utilisations d'un récepteur appelé GRP78 et d'autres récepteurs des cellules endothéliales qui se lient au domaine kringle 5 du plasminogène de mammifère. Plus particulièrement, l'identification des propriétés fonctionnelles de ce récepteur et d'autres récepteurs de ce type permet de développer et de cribler des agents qui, par exemple, imitent K5 (agents mimétiques) et donc inhibent l'angiogénèse.

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