Modified peptides with increased potency

Details Modified peptides with increased potency Modified peptides with increased potency

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/04 (2006.01) C07K 7/08 (2006.01) C07K 7/23 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/55 (2006.01) C07K 14/575 (2006.01) C07K 14/58 (2006.01) C07K 14/585 (2006.01) C07K 14/595 (2006.01) C07K 14/60 (2006.01) C07K 14/635 (2006.01) C07K 14/65 (2006.01) C07K 14/655 (2006.01) C07K 14/665 (2006.01) C07K 14/675 (2006.01) C07K 14/68 (2006.01) C07K 14/695 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2417100

The present invention is concerned with modified biological peptides providing increased potency, prolonged activity and/or increased half-life thereof. The modification is made via coupling through an amide bond with at least one conformationally rigid substituent, either at the N-terminal of the peptide, the C-terminal of the peptide, on a free amino or carboxyl group along the peptide chain, or at a plurality of these sites. Those peptides exhibit clinical usefulness for example in treating states of insulin resistance associated with pathologies such as type II diabetes.

L'invention concerne des peptides biologiques modifiés présentant une activité renforcée, une activité prolongée et/ou une demi-vie biologique améliorée. Cette modification s'effectue par couplage par liaison amide avec au moins un substituant conformationnellement rigide, soit au N-terminal du peptide, au C-terminal du peptide, sur un groupe carboxyle ou amino le long de la chaîne peptidique, soit sur plusieurs de ces sites. Ces peptides sont utiles sur le plan clinique, par exemple, pour le traitement d'états de résistance à l'insuline associés aux pathologies telles que les diabètes de type II.

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