C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/06 (2006.01) C07K 19/00 (2006.01) C12N 9/16 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2671060
The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.
La présente invention porte sur des peptides et des polypeptides ayant la séquence SAVTFAVCAL ou des variants de celle-ci, capables de se lier à la Calcineurine et/ou à NS5A-TP2, et sur leur utilisation en thérapie, ainsi que sur des séquences d'acide nucléique et des vecteurs codant pour ces peptides et polypeptides, et sur des cellules comprenant lesdits polypeptides, séquences d'acide nucléique ou vecteurs. L'invention porte en outre sur l'utilisation des peptides, des polypeptides ou de leurs dérivés pour conférer des changements phénotypiques dans des cellules de mammifère, en particulier, pour réguler de façon positive l'activité de la Calcineurine. L'invention porte enfin sur un procédé d'identification intracellulaire de substances qui se lient à la Calcineurine et qui modulent les effets physiologiques de la Calcineurine.
Colas Pierre
de Chassey Benoit
Mikaelian Ivan Jacques
Rudkin Brian B.
Centre National de La Recherche Scientifique
Ecole Normale Superieure de Lyon
Robic
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