A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/145 (2006.01) A61K 9/12 (2006.01)
Patent
CA 2201598
The invention relates to a vaccine composition adapted for mucosal administration, and in particular for intranasal administration, the composition comprising an influenza virus antigen or antigens, such as haemagglutinin and neuraminidase influenza virus antigens, and an effective adjuvant amount of a chitosan. The compositions can be used to immunise a host against infection with influenza, the chitosan serving to enhance the stimulation of a protective IgA mucosal immune response and an IgG systemic immune response.
L'invention concerne une composition vaccinale conçue pour une administration par la muqueuse, et en particulier par voie intra-nasale. Cette composition comprend un ou plusieurs antigènes du virus de la grippe, tels qu'une hémagglutinine et une neuraminidase, et une quantité adjuvante efficace d'un chitosane. De telles compositions permettent d'immuniser un hôte contre une infection grippale et le chitosane renforce la stimulation d'une réponse immunitaire protectrice due à l'IgA et une réponse immunitaire systèmique due à l'IgA.
Chatfield Steven Neville
Illum Lisbeth
Archimedes Development Limited
Danbiosyst Uk Limited
Marks & Clerk
Medeva Holdings B.v.
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