Transvascular and intracellular delivery of lipidized proteins

Details Transvascular and intracellular delivery of lipidized proteins Transvascular and intracellular delivery of lipidized proteins

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2118586

2118586 9401131 PCTABS00030 The invention provides methods for targeting a protein, such as an antibody, to intracellular compartments in a eukaryotic cell, methods for enhancing organ uptake of proteins, pharmaceutical compositions of modified proteins for use in human therapy, and methods for manufacturing modified proteins. The modified proteins of the invention comprise an attached lipid protein, wherein one or more acyl groups are linked to the protein through a carbohydrate side-chain and various covalent linkage chemistries which are provided. Lipidized antibodies of the invention can be used for diagnostic and therapeutic uses.

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