Method for identifying compounds with anti-herpes activity

Details Method for identifying compounds with anti-herpes activity Method for identifying compounds with anti-herpes activity

A - Human Necessities

61

K

A61K 39/245 (2006.01) A61P 31/22 (2006.01) C07D 277/54 (2006.01) C07D 417/12 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2412720

The invention relates to a method for identifying compounds with antiviral activity, characterized in that those compounds are selected in the presence of which resistant viral mutants can be selected, wherein at least one selected viral mutant carries at least one mutation in the primase gene and another selected viral mutant carries at least one mutation in the helicase gene or a selected viral mutant carries at least one mutation in the helicase and at least one mutation in the primase gene.

L'invention concerne une méthode d'identification de composés présentant une activité antivirale, qui est caractérisée en ce que ces composés sont sélectionnés en présence desquels des mutants viraux résistants peuvent être sélectionnés. Au moins un mutant viral sélectionné porte au moins une mutation dans le gène de la primase et un autre mutant viral sélectionné porte au moins une mutation dans le gène de l'hélicase, ou un mutant viral sélectionné porte au moins une mutation dans l'hélicase et au moins une mutation dans le gène de la primase.

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