Streptomyces avermitilis gene directing the ratio of b2:b1...

Details Streptomyces avermitilis gene directing the ratio of b2:b1... Streptomyces avermitilis gene directing the ratio of b2:b1...

C - Chemistry, Metallurgy

12

N

C12N 15/76 (2006.01) C07H 21/00 (2006.01) C07K 14/36 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01) C12N 15/52 (2006.01) C12P 19/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2521289

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

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