Antibody variants and fragments thereof

Details Antibody variants and fragments thereof Antibody variants and fragments thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 1/14 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2577543

A variant of a polypetide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326, 327, 324, 331, 333 or 334 of the human IgG Fe region. Such variants display altered effector funcdon. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be altered in the variant polypeptide. The application also discloses a variant of a parent polypeptide comprising a human IgG Fc region, which variant has a better binding affinity for human C1q than the parent polypeptide.

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