C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2691714
A method is disclosed for the determination of 5-ASA efficacy in preventing and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of the .beta.- catenin pathway in presence of 5-ASA. More in details, the method comprises measuring the expression of at least one gene involved in the regulation of the .beta.- catenin signalling pathway, such as -protocadherin, E-cadherin, .beta.- catenin, Axin1, ICAT, p21 waf-1 and the expression of onco-suppressor genes, such as KLF4 and CEBP.alpha.. Gene expression can be measured in accordance to the methods commonly available in the art such as QRT-PCR and immunohistochemistry.
Ferrarini Fabrizio
Grande Alexis
Parenti Sandra
Riches Mckenzie & Herbert Llp
Sofar Spa
LandOfFree
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