Modified aerolysin linked to a lung cancer binding agent and...

Details Modified aerolysin linked to a lung cancer binding agent and... Modified aerolysin linked to a lung cancer binding agent and...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C07K 14/33 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2517158

Disclosed herein are peptides that include aerolysin (or an aerolysin homolog) linked to an agent that specifically binds to a lung cancer cell, as well as nucleic acid sequences that encode such peptides. Methods of using such peptides and nucleic acid sequences to treat lung cancer are also disclosed.

L'invention concerne des peptides comprenant de l'aérolysine (ou un homologue d'aérolysine). Cette aérolysine est couplée à un agent qui se lie spécifiquement avec une cellule de cancer du poumon. L'invention concerne également des séquences d'acides nucléiques qui codent les peptides en question. L'invention concerne enfin des procédés relatifs à l'utilisation des peptides et des séquences d'acides nucléiques considérés pour le traitement du cancer du poumon.

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