Primary cultured adipocytes for gene therapy

Details Primary cultured adipocytes for gene therapy Primary cultured adipocytes for gene therapy

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/077 (2010.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/867 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2488414

The present invention relates to primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells. This invention provides cells suitable for gene therapy, which can replace bone marrow cells and liver cells used for conventional ex vivo gene therapy. The present invention established methods for transferring foreign genes into primary cultured adipocytes, which are suitable for ex vivo gene therapy; can be easily collected and implanted; and can be removed after implantation. Specifically, the present invention established these methods that use retroviral vectors. The present invention also established primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells.

Adipocytes de culture primaire utilisés en thérapie génique qui soutiennent de façon stable un gène étranger codant pour une protéine sécrétée de façon extracellulaire. Elle concerne notamment des cellules appropriées pour la thérapie génique utilisables en tant que substituts des cellules de la moelle osseuse ou des hépatocytes utilisés en thérapie génique in vivo. On a mis au point un procédé pour transférer un gène étranger dans des adipocytes de culture primaire, appropriés pour être utilisés en thérapie génique in vivo, qui peuvent être collectés et transplantés facilement puis éliminés après transplantation. On a mis au point notamment des adipocytes de culture primaire, destinés à la thérapie génique ex vivo, qui soutiennent de façon stable un gène étranger codant une protéine sécrétée de façon extracellulaire.

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